সোমবার, ৮ এপ্রিল, ২০১৩

Brain's stress circuits undergo profound learning early in life, scientists find

Apr. 7, 2013 ? Researchers at the University of Calgary's Hotchkiss Brain Institute have discovered that stress circuits in the brain undergo profound learning early in life. Using a number of cutting edge approaches, including optogenetics, Jaideep Bains, PhD, and colleagues have shown stress circuits are capable of self-tuning following a single stress. These findings demonstrate that the brain uses stress experience during early life to prepare and optimize for subsequent challenges.

The team was able to show the existence of unique time windows following brief stress challenges during which learning is either increased or decreased. By manipulating specific cellular pathways, they uncovered the key players responsible for learning in stress circuits in an animal model. These discoveries culminated in the publication of two back-to-back studies in the April 7 online edition of Nature Neuroscience.

"These new findings demonstrate that systems thought to be 'hardwired' in the brain, are in fact flexible, particularly early in life," says Bains, a professor in the Department of Physiology and Pharmacology. "Using this information, researchers can now ask questions about the precise cellular and molecular links between early life stress and stress vulnerability or resilience later in life."

Stress vulnerability, or increased sensitivity to stress, has been implicated in numerous health conditions including cardiovascular disease, obesity, diabetes and depression. Although these studies used animal models, similar mechanisms mediate disease progression in humans.

"Our observations provide an important foundation for designing more effective preventative and therapeutic strategies that mitigate the effects of stress and meet society's health challenges," he says.

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The above story is reprinted from materials provided by University of Calgary, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal References:

  1. Wataru Inoue, Dinara V Baimoukhametova, Tam?s F?zesi, Jaclyn I Wamsteeker Cusulin, Kathrin Koblinger, Patrick J Whelan, Quentin J Pittman, Jaideep S Bains. Noradrenaline is a stress-associated metaplastic signal at GABA synapses. Nature Neuroscience, 2013; DOI: 10.1038/nn.3373
  2. Jaclyn I Wamsteeker Cusulin, Tam?s F?zesi, Wataru Inoue, Jaideep S Bains. Glucocorticoid feedback uncovers retrograde opioid signaling at hypothalamic synapses. Nature Neuroscience, 2013; DOI: 10.1038/nn.3374

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/mind_brain/mental_health/~3/k7ZzaCJsu0Q/130407133314.htm

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রবিবার, ৭ এপ্রিল, ২০১৩

Senate nears gun debate, background checks pivotal

WASHINGTON (AP) ? Congress returns Monday from a two-week spring recess with gun control and immigration high on the Senate's agenda.

Senators could start debating Democratic-written gun legislation before week's end. But leaders also might decide to give negotiators more time to seek a deal on expanding background checks for firearms buyers.

Passing the expanded background checks would be viewed as a victory for gun-control advocates after Democratic leaders made it clear that supporters were nowhere close to getting a majority of votes in favor of reinstituting an assault weapons ban.

Both measures have been a priority for President Barack Obama since the Dec. 14 shooting at an elementary school in Newtown, Conn. On Monday Obama travels to Connecticut to again make the case for gun legislation, with a speech at the University of Hartford.

"He's been working with both sides to try to get the strongest bill we can that has enforceable background checks," White House senior adviser Dan Pfeiffer said Sunday on ABC's "This Week."

The National Rifle Association opposes both the assault weapons ban and the expanded background checks.

Short of unanimous support in their own party, Democratic senators have been unable to strike a deal with Republicans for the votes they would need to push background check legislation through the chamber. Senate Majority Leader Harry Reid, D-Nev., might delay debate to give bargainers more time, underscoring how crucial the proposal is to the gun control drive.

"If we go to the floor, I'm still hopeful that what I call the sweet spot ? background checks ? can succeed," Sen. Chuck Schumer, D-N.Y., said Sunday, referring to the start of debate by the full Senate. "We're working hard there."

Dan Gross, president of the Brady Campaign to Prevent Gun Violence, called the measure "the most pivotal piece" of Democrats' gun legislation.

Also high on Congress' agenda is immigration, where a decisive moment is approaching.

Bipartisan groups in the House and Senate are expected to present legislation as early as this week aimed at securing the U.S. border, fixing legal immigration and granting legal status to millions who are in the United States without authorization. That will open months of debate on the politically combustible issue, with votes by the Senate Judiciary Committee expected later this month.

The House is looking at a busy, if more low-profile agenda in the coming weeks.

In its first week back, the House will consider a bill that would prevent the National Labor Relations Board from issuing rules until a dispute over administration appointees is resolved.

Among the bills that could see action in later weeks is a measure requiring the Treasury to pay principle and interest on debt held by the public if the nation's borrowing limit is reached but not extended.

Other measures would prioritize pediatric research to assist children with autism and give workers greater flexibility to choose paid time off instead of overtime pay.

Lawmakers will devote much time to the 2014 budget proposal that Obama plans to release on Wednesday. It calls for both new tax increases, which Republicans oppose, and smaller annual increases in Social Security and other government benefit programs, over the objections of many of the president's fellow Democrats.

Even with a background check deal, Senate debate on gun legislation may begin at a slow crawl with some conservatives promising delays and forced procedural votes. Sen. John McCain, R-Ariz., on Sunday urged fellow Republicans to allow debate to go forward, even as he declined to express support for a background check bill.

"I don't understand it. The purpose of the United States Senate is to debate and to vote and to let the people know where we stand," McCain said, appearing alongside Schumer on CBS' "Face the Nation."

There's a strong chance the first votes won't occur until at least mid-April.

Until Democrats come out with the final shape of their background check measure, gun control advocates nervously are tracking the private negotiations, worried their allies might cut a deal that goes too far.

"We want a vote on the issues, we don't want them watered down so they're unrecognizable," said Joshua Horwitz, executive director of the Coalition to Stop Gun Violence. "If they can't vote for it, let the American people judge them on that. Don't let a dumbed-down bill be the outcome of this."

The Senate gun legislation would toughen federal laws against illegal firearms sales, including against straw purchasers, or those who buy firearms for criminals or others barred from owning them. The legislation also would provide $40 million a year, a modest increase from current levels of $30 million, for a federal program that helps schools take safety measures such as reinforcing classroom doors.

Omitted from the bill are bans on assault weapons and high capacity ammunition magazines, both factors in the shooting at Sandy Hook Elementary School. Those bans were approved last month by the Senate Judiciary panel. Reid has said he will allow both to be offered as amendments by their sponsor, Sen. Dianne Feinstein, D-Calif., but neither seems likely to survive.

Many experts agree that the proposal with the widest potential reach is a broadening of background checks, now required only for transactions by the roughly 55,000 federally licensed firearms dealers. Proponents want to cover private sales, such as those between individuals at gun shows or online.

One major hang-up has been Democrats' insistence on retaining records of private sales, which they say is the best way to ensure background checks are actually conducted. Sen. Tom Coburn, R-Okla., a leader of conservatives in the talks, has rejected that as excessive government intrusiveness.

The system is aimed at preventing guns from going to criminals, people with severe mental problems, some drug abusers and others.

The National Rifle Association and other critics say the checks are ignored by criminals, and they fear that expanding the system could be a prelude to the government maintaining files on gun owners. Current law forbids that. The government must destroy records of the checks within a day, though gun dealers must retain information on the transactions for 20 years.

"We remain committed in our opposition to expanding a broken system," said NRA lobbyist Chris W. Cox.

Justice Department figures show that from 1994 when the system began through 2010, 118 million would-be gun buyers were checked and 2.1 million were denied firearms. Defenders say the data proves the checks prevent many dangerous people from getting weapons.

The current background check measure, by Schumer, would expand the system to cover nearly all gun transactions, with narrow exceptions that include sales involving immediate relatives such as parents and children. Even without a bipartisan deal, Schumer is expected to expand the exemptions to more relatives, people with permits to carry concealed weapons and others.

Schumer and Sens. Joe Manchin, D-W.Va., and Mark Kirk, R-Ill., have been shopping alternatives in an effort for more GOP support. Democrats are sure to need 60 votes in the 100-member chamber to win, but there are just 53 Democratic senators plus two Democratic-leaning independents.

Democrats have considered requiring background checks for all gun show and online sales, but exempt face-to-face transactions between private individuals who do not run commercial gun enterprises.

Source: http://news.yahoo.com/senate-nears-gun-debate-background-checks-pivotal-135943889--politics.html

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Miley Cyrus Boyish Fashion Fail!

Miley Cyrus is actually pretty fashion forward…okay maybe not so much. But you have to give her credit for trying. In this case, maybe she tried too hard. Seriously, in this pic, it looks like she raided a middle school boy’s locker. She needs to really grow back some hair, and put on some more lady like clothing. Not that I care about gender roles, but when you are skinny with short hair, it’s just a little awkward to wear clothes like that. As for the bright lipstick. I guess it works with certain outfits, but it’s ridiculous to wear dark shorts and a tank top with bright lip stick. The contrast doesn’t do anything for her. So for now Miley, you’ve earned a strong Fashion Fail. And yes, we are picking on you on purpose. You have potential and always manage to leave yourself looking disheveled. Readers: what do you think about the pic?

Source: http://feedproxy.google.com/~r/RightCelebrity/~3/HfqYhA583Bo/

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Yes, New Jersey does have online gambling already ? on horse races

Did you know that more than $90 million was bet online in New Jersey last year on horse racing?

Did you even know that it was legal to bet on horse racing online?

Many Meadowlands Matters regulars are horsemen, so they all knew it.

But a 2010 poll found that not only were just 10 pct of state residents aware, 35 pct incorrectly said it was NOT legal.

So I put together a little primer/history lesson for today?s edition of The Record.

And even horsemen can check their sense of where betting takes place against my chart within the link listing the 2012 figures for on-track, at OTWs, online, and at Atlantic City casinos.

The state, of course, is looking to offer lots more gambling online by the end of the year ? not only online poker, but any casino game that gets the go-ahead from the state Division of Gaming Enforcement.

It?s a brave new world ? welcomed by some, feared by others. This article was to show what we already have.

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Source: http://blog.northjersey.com/meadowlandsmatters/5482/yes-new-jersey-does-have-online-gambling-already-on-horse-races/

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University of Tampa lacrosse team opens new stadium Friday

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By BY ELIZABETH BEHRMAN |
Published: April 5, 2013

SOUTH TAMPA - For Eric Dance, senior captain of the University of Tampa lacrosse team, Friday?s match will be bittersweet.

It is both the first and last game he will play in the university?s new lacrosse stadium on the north side of Kennedy Boulevard, which was completed just in time for the last home game of the regular season.

?I?m excited,? Dance said. ?It?s going to be really nice.?

The 90,000-square-foot field was supposed to be done in time for the first lacrosse game of the season in February, but construction took longer than expected, university officials said. The stadium will be dedicated before the 8 p.m. game Friday, and admission will be free for anyone who wants to watch the first game in the new complex.

Easily distinguished by a 60-foot-high black net beside Kennedy Boulevard, the Naimoli Family Athletic and Intramural Complex will be the permanent home of the university?s lacrosse team.

?This stadium sends the message that the university is committed to this program, and it?s here to stay,? said Athletic Director Larry Marfise.

The men?s team was formed two years ago and the university has hired a coach for a women?s team, which currently is recruiting for next season, he said.

Eventually other teams and intramural squads also will use the field.

The team, with a won-loss record of 8-4 so far this season, didn?t get on the playing surface of its new home until Monday?s practice, Dance said. Until then, the team played at the university?s Pepin Stadium.

?It gets a lot of use,? he said. ?There?s a lot of holes in it now. I know the soccer teams are happy we?re moving.?

Dance, who went to Freedom High School in New Tampa, transferred to UT from Salisbury University in Maryland to be part of the new lacrosse program. He said he believes the new stadium will draw a lot of fans and potential recruits.

?Having such a nice stadium is definitely going to bring a lot of kids to the school,? Dance said.

Marfise said the lacrosse program already has attracted about 100 male students to the school, although the team was not formed for that purpose.

Lacrosse, first played by Native Americans, is quickly gaining popularity in Florida, Marfise said. When the university decided it wanted to introduce a new team and build a new athletic complex, lacrosse was an easy choice.

?We really thought it would be a good fit,? Marfise said. ?Something new.?

Source: http://feedproxy.google.com/~r/tbo/southtampa/~3/__iX_hW2kLA/university-of-tampa-lacrosse-team-opens-new-stadium-friday-b82472666z1

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Only weeks after amputation, combat vet swoops slopes with Sochi dreams

U.S. Department of Veteran Affairs

Carlos Figueroa monoskis in Aspen Snowmass on Thursday as part of a VA sports clinic for disabled veterans.

By Bill Briggs, NBC News contributor

An Iraq war veteran who yearns to snowboard next March at the Sochi Paralympics recently told a priest he would give his left leg to compete for his country. And then, he did.

Six weeks ago, retired Army Sgt. Carlos Figueroa allowed a surgeon to amputate below his left knee ? 10 years after an IED blast rendered the limb nearly useless. The decision was surprisingly simple, he said, because it sliced away a decade of mounting pain. Yet he also acknowledged: ?I did give it up because I want to get into the Paralympics.?

?When I went in, my doctor asked me: ?What?s your biggest goal?? I told him: ?Be on my board within three months.? He just said, ?Dude, most people aren?t walking within three months,? ? Figueroa recalled.?

Walking will come. What he can do ? already ? is carve down a mountain, the lone place Figueroa, 34, feels at peace: ?Up there, I?m no different from anybody. No PTSD. I?m at my happiest.? On Thursday, Figueroa beamed while manhandling an Aspen, Colo., slope atop a monoski at a sports clinic for disabled veterans. As a familiar, cool breeze brushed his face, he also dreamed?about racing in Russia.


?My love for snowboarding is about loss, the loss of what I had in the military, where you?re used to being on the move, on patrols, on raids. That?s how I treat my races. The moment that gate drops, it?s like the door opening on a raid. I go full blast. I?m able to get something back that I felt was taken away. That rush. I love it.?

U.S. Department of Veteran Affairs

"Up there, I'm no different from anybody. No PTSD. I'm at my happiest," said Carlos Figueroa of the feeling of carving down slopes.

The wars in Iraq and Afghanistan have borne a bittersweet byproduct: scores of American Paralympic hopefuls. The Sochi Paralympics, to be held just after the 2014 Winter Games in that city, marks the inaugural Paralympic snowboarding event for disabled athletes. The U.S. men?s Paralympic snowboarding squad will consist of five members.

'Slim chance'
Figueroa (and those close to him) knows he?s the longest of long shots. His own coach, Mike Shea, estimates he took two years to, literally, make the leap from his own leg amputation to landing jumps. The raw nerve endings in an amputated limb must become desensitized to the harsh pounding. When the board hits the snow, the stump pushes into the prosthetic leg, ?sending chills up your spine,? Shea said. ?It doesn?t feel good.?

Then there?s the calendar. If Figueroa is indeed back on his board by autumn, he?ll have a limited number of sanctioned races ? beginning in January 2014 ? to rack up enough points to rank among the top five American men. And the U.S. Paralympic snowboarders, including Shea, compose the world?s deepest talent pool in that sport. The roster likely will be named in February.

?It?s a slim chance, a super, super small window,? Figueroa said, ?but we?re still going to push.?

He needs only a sliver of possibility to kindle his hope ? or better yet, someone telling him he can?t. He certainly doesn?t need two legs.

The Feb. 15 amputation came 10 years after a bomb detonated beneath his armored vehicle, ejecting him through an open roof hatch. A decade spent lugging a useless left limb (with no heel), suffering increasing back and knee pain, instantly convinced him to say ?Let?s do it,? when an orthopedic surgeon in San Diego suggested, ?Let?s cut.? He was done, he said, wasting another day ?in a bubble? due to his injury, calling the operation ?liberating.?

'Go fast and have fun'
Nobody who has heard that account is betting against Figueroa.

?With any military athlete, you can definitely see that sense of pride and determination above and beyond what you see with other athletes. Part of it is just a chance to represent their county again,? said Kevin Jardine, high performance director of Parlaympic alpine skiing and snowboarding for the U.S. Olympic Committee. ?They?re willing to sacrifice a lot.?

Added Shea, who lost his leg in a 2002 wake-boarding accident: ?Anything you tell Carlos, he?ll get it done. He always seems to find a way. He has no fear up there. He has passion. And I?ve learned from him the smiling gets you a long way in life.?

This week at the National Disabled Veterans Winter Sports Clinic in Aspen, organized by the Department of Veterans Affairs, Figueroa has been tempted to grab a board and shred. This is his fourth year attending. As a testament to his disregard for other people?s timelines, he couldn?t even stand on a snowboard four years ago due to his injury, yet he competed in a World Cup event for disabled snowboarders not long after that.

Until his prosthetic leg arrives, he?ll stick to monoskiing, during which he sits in a ?bucket? atop one ski, using his arms to hold smaller, balancing skis.

?The first run, I took it slow. After that, I opened it up,? Figueroa said. ?I just want to go fast and have fun.?

When the instructor noticed his raw speed, he warned Figueroa: ?You do realize if you go down, you may peel off half your face.?

Figueroa simply grinned: ?That?s alright.?

On the 10th anniversary of the war in Iraq, a special group of people in Vail, Colo., are also marking the tenth anniversary of their unique program designed to help war amputees regain independence through skiing. NBC's Kevin Tibbles reports.

Related:?

Source: http://feeds.nbcnews.com/c/35002/f/653387/s/2a686853/l/0Lusnews0Bnbcnews0N0C0Inews0C20A130C0A40C0A60C175898670Eonly0Eweeks0Eafter0Eamputation0Ecombat0Evet0Eswoops0Eslopes0Ewith0Esochi0Edreams0Dlite/story01.htm

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